Brad Zuchero || Assistant Professor
Dr. J. Bradley Zuchero is an Assistant Professor in the Department of Neurosurgery, Stanford University School of Medicine. Brad has a longstanding interest in how cells in the brain interact to build a functional nervous system, regulate its function in adults, and how these interactions are perturbed in disease.
Brad grew up in the woods of Pennsylvania, becoming interested in science at a young age with the encouragement of his teacher parents. He majored in biology at Vassar College, where he first fell in love with research. Brad did his Ph.D. work with Dr. Dyche Mullins at UCSF, discovering and characterizing a novel protein that builds actin filaments in cells. In his postdoctoral work with Dr. Ben Barres at Stanford, he brought his expertise in cell biology to the study of how oligodendrocytes form myelin, with the goal of understanding why myelination commonly fails in diseases like multiple sclerosis (MS).
While working with Dr. Barres, Brad discovered that formation of myelin in the central nervous system occurs by a surprising and seemingly paradoxical mechanism: the actin cytoskeleton that is required for most cells to change shape and move is taken apart at the start of myelination. Understanding this mechanism, and testing whether it is perturbed in diseases affecting myelination is now a major research goal of his lab. Brad hopes that work in his lab will contribute to cures for MS and other diseases of the nervous system.
Brad has received awards for his work including a Career Transition Award from the National MS Society, a Life Sciences Research Foundation postdoctoral fellowship, the Discovery Science Award and Pioneer Award from the Myelin Repair Foundation, a Research Award from the Marine Biological Laboratory in Woods Hole, and a predoctoral fellowship from the American Heart Association.
Some of his best ideas have come while cycling, running, or hiking around Northern California.
Manasi Iyer || PhD Student
Manasi is a graduate student in the Neurosciences PhD Program. In the Zuchero lab, she hopes to better understand the molecular and cellular mechanisms that underlie myelination. Before joining the neuroscience PhD program at Stanford, Manasi earned her BA in biology from Williams College. After college, she went on to work as a research technician in Saul Villeda’s lab at UCSF, where she studied the role of novel epigenetic regulators of brain aging and rejuvenation. When she is not in lab, Manasi spends her time reading and replicating recipes from The Smitten Kitchen and petting every dog on Stanford’s campus.
Husniye Kantarci, PhD || Postdoctoral fellow
Husniye is a postdoctoral fellow in the Zuchero lab, and winner of a 2017 Stanford ChEM-H Postdocs at the Interface seed grant and a Stanford School of Medicine Dean's Postdoctoral Fellowship. She is very interested in discovering the signals that enable the communications between the glial cells and neurons, and understanding how these signals regulate neural function and myelination in the nervous system. Husniye attended Boğaziçi University in Istanbul, Turkey and majored in Molecular Biology and Genetics. She became fascinated with neural development during her undergraduate work and joined Dr. Bruce Riley’s lab at Texas A&M University for doctoral studies to study the genes and signaling pathways that regulate development of the inner ear neurons. During her PhD, Husniye characterized the signaling pathways that control formation, migration, and differentiation of inner ear neurons and discovered novel genes and mechanisms that govern inner ear neurogenesis. During her postdoctoral work, she is hoping elucidate novel pathways that regulate the interactions between the cells of the nervous system and characterize the role of disruptions in pathways in diseases of the brain. Husniye plans to power her postdoctoral work with hiking, cycling, climbing and running the wonderful trails of California.
Kathryn Wu || MD-PhD Student
Kathryn is a student in the Medical Scientist Training Program. She is interested in understanding the process of myelination and how it goes awry in disease. Kathryn first fell in love with biology during her undergraduate training at Swarthmore College, where she started out studying invasive species and soil respiration in the Crum Woods with Dr. Jose-Luis Machado. She eventually found her way to an air conditioned lab at the University of Pennsylvania, where she studied epigenetic changes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) under Dr. Edward Lee. After finishing college, Kathryn joined Dr. Robert Baloh's lab at Cedars Sinai Medical Center, where she worked on developing and characterizing cellular models for ALS and FTD . Outside of lab and class, Kathryn enjoys going to bible study, climbing rocks both indoors and outdoors, and attempting to dance west coast swing.