Tal and Miguel’s preprint posted on Bioarchives

Posted Posted in Uncategorized

Our preprint, “SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination,” uncovers the transcription factor SRF as a new regulator of myelination required cell-autonomously in oligodendrocytes for expression of genes, including actin-related genes. Preprint available here: https://www.biorxiv.org/content/10.1101/2022.09.21.508765v1

Mable and Koji’s paper is out in Nature Communications

Posted Posted in Uncategorized

Our paper, “CNS myelination requires VAMP2/3-mediated membrane expansion in oligodendrocytes”, reveals that developmental myelination requires exocytosis in oligodendrocytes to add new membrane and adhesion proteins. This sets the stage for ongoing work to understand how exocytosis is regulated (e.g. by neuronal activity) and whether this pathway is dysregulated in disease. Congrats to Mable, Koji, and […]